Treatment of vitamin D deficiency


In cases of severe vitamin D deficiency, for example, patients with diagnosed bone diseases or who are using antiresorptive medications, loading regimens may be required.1 The intention of these is to correct vitamin D status rapidly.  Loading doses of up to 7,500 µg (300,000 IU) have been advised by the National Osteoporosis Society1,  given as weekly or daily split doses.  So, for example, taking a 100 µg tablet per day (4000 IU), for 10 weeks (total of 280,000 IU) could be used in the rapid correction of vitamin D deficiency.1 Without exceeding the EFSA Upper Limit.2  It should be considered, however, that supplements are best taken with food to aid absorption.1

Patients should continue taking a long term maintenance dose of vitamin D3. (see maintenance section)


  1. National Osteoporosis Society (2016). Vitamin D and Bone Health: A Practical Clinical Guideline for Patient Management. Accessed online: (April 2016).
  2. European Food Safety Authority (2012). Scientific Opinion on the Tolerable Upper Intake Level of Vitamin D. EFSA Panel of Dietetic Products, Nutrition and Allergies. EFSA Journal; 10(7): 2813.